Immune-reactive soluble OX40 ligand, soluble CD40 ligand, and interleukin-27 are simultaneously oversecreted in platelet components associated with acute transfusion reactions.

@article{Hamzehcognasse2014ImmunereactiveSO,
  title={Immune-reactive soluble OX40 ligand, soluble CD40 ligand, and interleukin-27 are simultaneously oversecreted in platelet components associated with acute transfusion reactions.},
  author={H Hamzeh-cognasse and Pauline Damien and Kim Anh Nguyen and Charles-Antoine Arthaud and Marie-Ange Eyraud and Patricia Chavarin and L{\'e}na Absi and Jean-Claude Osselaer and Bruno Pozzetto and Fabrice Cognasse and Olivier Garraud},
  journal={Transfusion},
  year={2014},
  volume={54 3},
  pages={
          613-25
        }
}
BACKGROUND Leukoreduction of labile blood components dramatically decreases the frequency of minor, intermediate, and severe adverse events (AEs), referred to as acute transfusion reactions (ATRs), especially after transfusion of platelet components (PCs). The pathophysiology of AEs may result from accumulation of soluble, secreted, platelet (PLT) factors with proinflammatory functions stored in PCs. Thus, several cosynergizing factors associated with PLT accumulation in PCs may contribute to… CONTINUE READING
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