Immune reactive cells in senile plaques and cognitive decline in Alzheimer’s disease

@article{Vehmas2003ImmuneRC,
  title={Immune reactive cells in senile plaques and cognitive decline in Alzheimer’s disease},
  author={Anne K Vehmas and Claudia H Kawas and Walter F. Stewart and Juan C Troncoso},
  journal={Neurobiology of Aging},
  year={2003},
  volume={24},
  pages={321-331}
}
We examined the associations of postmortem neocortical immunoreactivities for microglia, astrocytes, Abeta and Tau with cognitive changes in clinically characterized subjects with pathological diagnoses (CERAD classification) of definite AD (9), possible AD (15) and age-matched controls (11). By measuring the fractional area (FA) of immunoreactivity, we found that Abeta deposits appear early in the pathogenesis of Abeta, but cannot account for cognitive decline. We found a significant increases… CONTINUE READING

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