Immune protection against foot-and-mouth disease virus studied using virus-neutralizing and non-neutralizing concentrations of monoclonal antibodies.

@article{McCullough1986ImmunePA,
  title={Immune protection against foot-and-mouth disease virus studied using virus-neutralizing and non-neutralizing concentrations of monoclonal antibodies.},
  author={Kenneth C McCullough and John R. Crowther and R N Butcher and William C. Carpenter and Emiliana Brocchi and Lorenzo Capucci and Filippo De Simone},
  journal={Immunology},
  year={1986},
  volume={58 3},
  pages={
          421-8
        }
}
Monoclonal antibodies (MAb) against sequential or conformational epitopes on foot-and-mouth disease virus (FMDV) passively protected neonatal syngeneic (BALB/c) mice at dilutions at which they could not neutralize virus infectivity in vitro. The B2, D9, 1C6 and 4C9 MAb, against the Group 1 (sequential) and Group 2 (conformational) epitopes, protected the mice at an antibody:virion molar ratio of between 38:1 and 84:1 (12-18 times lower than that required for neutralization of virus infectivity… CONTINUE READING

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