Immune privilege and HIV-1 persistence in the CNS.

@article{Persidsky2006ImmunePA,
  title={Immune privilege and HIV-1 persistence in the CNS.},
  author={Yuri Persidsky and Larisa Poluektova},
  journal={Immunological reviews},
  year={2006},
  volume={213},
  pages={
          180-94
        }
}
Human immunodeficiency virus-1 (HIV-1) neuroinvasion occurs early (during period of initial viremia), leading to infection of a limited amount of susceptible cells with low CD4 expression. Protective cellular and humoral immunity eliminate and suppress viral replication relatively quickly due to peripheral immune responses and the low level of initial central nervous system (CNS) infection. Upregulation of the brain protective mechanisms against lymphocyte entry and survival (related to immune… CONTINUE READING
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