Immune-potentiation of Pneumococcal Capsular Polysaccharide Antigen using Albumin Microparticles

  title={Immune-potentiation of Pneumococcal Capsular Polysaccharide Antigen using Albumin Microparticles},
  author={Bernadette D’souza and P. N. Shastri and Gabrielle M. Hammons and Ellie Kim and L. Kolluru and G. Carlone and Gowrisankar Rajam and M. D'souza},
  journal={Journal of Pharmacovigilance},
  • Bernadette D’souza, P. N. Shastri, +5 authors M. D'souza
  • Published 2018
  • Chemistry
  • Journal of Pharmacovigilance
  • Microparticles (MPs) offer several advantages as unique vaccine delivery system, including the ease to manufacture, targeted delivery of antigen payload, sustained antigen release and possible role as an immuneadjuvant. In this study, we evaluated albumin matrix for pneumococcal (Pnc) serotype specific capsular polysaccharide (PS) antigen MPs. Microencapsulation of Pnc PS was successful with a product yield of >72%. The MP size, 1-5 μm, and negative zeta potential (-26.5 mV) were optimized to… CONTINUE READING
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