Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodies.


Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. bnAbs occur in some HIV-1-infected individuals and frequently have characteristics of autoantibodies. We have studied cohorts of HIV-1-infected individuals who made bnAbs and compared them with those who did not do so, and determined immune traits associated with… (More)
DOI: 10.1126/sciimmunol.aag0851

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