Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies

@article{Moody2016ImmunePI,
  title={Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies},
  author={Michael A. Moody and Isabela Pedroza-Pacheco and Nathan A. Vandergrift and Cecilia Chui and Krissey E. Lloyd and R. Parks and Kelly Soderberg and Ane Ogbe and Myron S. Cohen and Hua-Xin Liao and Feng Gao and Andrew J McMichael and David C. Montefiori and Laurent Verkoczy and Garnett H. Kelsoe and Jinghe Huang and Patrick R. Shea and Mark Connors and Persephone Borrow and Barton F. Haynes},
  journal={Science Immunology},
  year={2016},
  volume={1},
  pages={aag0851-aag0851}
}
Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. bnAbs occur in some HIV-1–infected individuals and frequently have characteristics of autoantibodies. We have studied cohorts of HIV-1–infected individuals who made bnAbs and compared them with those who did not do so, and determined immune traits associated with the ability to produce bnAbs. HIV-1–infected individuals with bnAbs had a higher frequency of blood autoantibodies, a lower frequency of… CONTINUE READING