Immune parameters correlate with protection against ebola virus infection in rodents and nonhuman primates.

@article{Wong2012ImmunePC,
  title={Immune parameters correlate with protection against ebola virus infection in rodents and nonhuman primates.},
  author={Gary W-K Wong and J. Stephen Richardson and St{\'e}phane Pillet and Ami Patel and Xiangguo Qiu and Judie Alimonti and Jeff Foster Hogan and Yi Irvette Zhang and Ayato Takada and Heinz Feldmann and Gary P Kobinger},
  journal={Science translational medicine},
  year={2012},
  volume={4 158},
  pages={158ra146}
}
Ebola virus causes severe hemorrhagic fever in susceptible hosts. Currently, no licensed vaccines or treatments are available; however, several experimental vaccines have been successful in protecting rodents and nonhuman primates (NHPs) from the lethal Zaire ebolavirus (ZEBOV) infection. The objective of this study was to evaluate immune responses correlating with survival in these animals after lethal challenge with ZEBOV. Knockout mice with impaired ability to generate normal T and/or B cell… CONTINUE READING
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