• Biology, Medicine
  • Published in Journal of immunology 1971

Immune paralysis induced by pneumococcal polysaccharide. II. Studies with peritoneal and spleen cell extracts and RNA.

@article{Williams1971ImmunePI,
  title={Immune paralysis induced by pneumococcal polysaccharide. II. Studies with peritoneal and spleen cell extracts and RNA.},
  author={Craig C. Williams and W G Wu},
  journal={Journal of immunology},
  year={1971},
  volume={107 1},
  pages={
          163-71
        }
}
Passive transfer methods demonstrated that disrupted peritoneal cells (PC) and spleen cells (SpC) from mice immunized or immunologically paralyzed with type III pneumococcal polysaccharide antigen (SIII) could induce specific protection against infection in normal recipients. A part of this response to cell extracts could be ascribed to RNase-sensitive material. Injection of RNA derived from PC of such donors led to antibody production in recipients, and the inducing substance was partially… CONTINUE READING

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