Immune modulation induced by tuberculosis DNA vaccine protects non-obese diabetic mice from diabetes progression.

@article{Jnior2007ImmuneMI,
  title={Immune modulation induced by tuberculosis DNA vaccine protects non-obese diabetic mice from diabetes progression.},
  author={R Rodrigues dos Santos J{\'u}nior and Alexandrina Sartori and V{\^a}nia Luiza Deperon Bonato and A A M Coelho Castelo and Conceiç{\~a}o Aparecida Vilella and Ricardo de Lima Zollner and C{\'e}lio Lopes Silva},
  journal={Clinical and experimental immunology},
  year={2007},
  volume={149 3},
  pages={570-8}
}
We have described previously the prophylactic and therapeutic effect of a DNA vaccine encoding the Mycobacterium leprae 65 kDa heat shock protein (DNA-HSP65) in experimental murine tuberculosis. However, the high homology of this protein to the corresponding mammalian 60 kDa heat shock protein (Hsp60), together with the CpG motifs in the plasmid vector, could trigger or exacerbate the development of autoimmune diseases. The non-obese diabetic (NOD) mouse develops insulin-dependent diabetes… CONTINUE READING

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