Immune modulation by multifaceted cationic host defense (antimicrobial) peptides.

@article{Hilchie2013ImmuneMB,
  title={Immune modulation by multifaceted cationic host defense (antimicrobial) peptides.},
  author={Ashley L. Hilchie and Kelli Wuerth and Robert E W Hancock},
  journal={Nature chemical biology},
  year={2013},
  volume={9 12},
  pages={
          761-8
        }
}
Cationic host defense (antimicrobial) peptides were originally studied for their direct antimicrobial activities. They have since been found to exhibit multifaceted immunomodulatory activities, including profound anti-infective and selective anti-inflammatory properties, as well as adjuvant and wound-healing activities in animal models. These biological properties suggest that host defense peptides, and synthetic derivatives thereof, possess clinical potential beyond the treatment of antibiotic… CONTINUE READING

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