Immune modulation by a high molecular weight fraction from the rat tapeworm Hymenolepis diminuta.

@article{Wang2005ImmuneMB,
  title={Immune modulation by a high molecular weight fraction from the rat tapeworm Hymenolepis diminuta.},
  author={Ai-lan Wang and D M McKay},
  journal={Parasitology},
  year={2005},
  volume={130 Pt 5},
  pages={575-85}
}
The host-parasite relationship is exquisitely specific. In exploiting the host niche, a variety of helminth parasites have been shown to directly manipulate their hosts' immune responses. We assessed the ability of a whole-worm extract of Hymenolepis diminuta to modulate immune cell activation. Immune cells isolated from human blood or rodent spleens were activated with the T cell mitogen, concanavalin A (Con A) +/- H. diminuta extract and cytokine production (i.e. IL-2, -4, -10, -12) and… CONTINUE READING
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