Immune modulation by Lacto-N-fucopentaose III in experimental autoimmune encephalomyelitis.

  title={Immune modulation by Lacto-N-fucopentaose III in experimental autoimmune encephalomyelitis.},
  author={Bing Zhu and Subbulaxmi Trikudanathan and Alla L. Zozulya and Carolina Sandoval-Garcia and Jennifer K. Kennedy and Olga Atochina and Thomas Norberg and Bastien Castagner and Peter H Seeberger and Zsuzsa Fabry and Donald H Harn and Samia J Khoury and Indira Guleria},
  journal={Clinical immunology},
  volume={142 3},
Parasitic infections frequently lead to immune deviation or suppression. However, the application of specific parasitic molecules in regulating autoimmune responses remains to be explored. Here we report on the immune modulatory function of Lacto-N-fucopentaose III (LNFPIII), a schistosome glycan, in an animal model for multiple sclerosis. We found that LNFPIII treatment significantly reduced the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation, and skewed… CONTINUE READING
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