Immune modulation and tolerance induction by RelB-silenced dendritic cells through RNA interference.

@article{Li2007ImmuneMA,
  title={Immune modulation and tolerance induction by RelB-silenced dendritic cells through RNA interference.},
  author={Mu J Li and Xusheng Zhang and Xiufen Zheng and Dameng Lian and Zhu-Xu Zhang and Weiwen Ge and Jinming Yang and Costin Vladau and Motohiko Suzuki and Dong Chen and Robert Zhong and B. Bueno Garc{\'i}a and Anthony M Jevnikar and Weiping Min},
  journal={Journal of immunology},
  year={2007},
  volume={178 9},
  pages={5480-7}
}
Dendritic cells (DC), the most potent APCs, can initiate the immune response or help induce immune tolerance, depending upon their level of maturation. DC maturation is associated with activation of the NF-kappaB pathway, and the primary NF-kappaB protein involved in DC maturation is RelB, which coordinates RelA/p50-mediated DC differentiation. In this study, we show that silencing RelB using small interfering RNA results in arrest of DC maturation with reduced expression of the MHC class II… CONTINUE READING