Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis.

@article{Romero2013ImmunemediatedPP,
  title={Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis.},
  author={Violeta Romero and Justyna Fert-Bober and Peter A Nigrovic and Erika Darrah and Uzma Jalal Haque and David M Lee and Jennifer van Eyk and Antony Rosen and Felipe Andrade},
  journal={Science translational medicine},
  year={2013},
  volume={5 209},
  pages={209ra150}
}
Autoantibodies to citrullinated protein antigens are specific markers of rheumatoid arthritis (RA). Although protein citrullination can be activated by numerous stimuli in cells, it remains unclear which of these produce the prominent citrullinated autoantigens targeted in RA. In these studies, we show that RA synovial fluid cells have an unusual pattern of citrullination with marked citrullination of proteins across the broad range of molecular weights, which we term cellular… CONTINUE READING
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