Immune-mediated parasite clearance in mice infected with Plasmodium berghei following treatment with manzamine A

@article{Ang2001ImmunemediatedPC,
  title={Immune-mediated parasite clearance in mice infected with Plasmodium berghei following treatment with manzamine A},
  author={Kenny Kean-Hooi Ang and Michael D. Holmes and Ursula A. K. Kara},
  journal={Parasitology Research},
  year={2001},
  volume={87},
  pages={715-721}
}
  • Kenny Kean-Hooi Ang, Michael D. Holmes, Ursula A. K. Kara
  • Published in Parasitology Research 2001
  • Biology, Medicine
  • Abstract. Manzamine A, a sponge-derived alkaloid, was recently shown to possess in vivo antimalarial activity against the blood stages of the rodent malaria parasite Plasmodium berghei. A single intraperitoneal dose of 100 µmol/kg of manzamine A suppressed parasite growth but was followed by parasite recrudescence. Forty percent of mice with recrudescing parasites were able to recover and clear the fulminating parasitaemia. Examination of sera from these mice revealed that infected mice treated… CONTINUE READING

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