Immune-mediated drug-induced liver disease.

  title={Immune-mediated drug-induced liver disease.},
  author={Zhang-Xu Liu and Neil Kaplowitz},
  journal={Clinics in liver disease},
  volume={6 3},
Drug-induced immune-mediated hepatic injury is an adverse immune response against the liver that results in a disease with hepatitic, cholestatic, or mixed clinical features. Drugs such as halothane, tienilic acid, dihydralazine, and anticonvulsants trigger a hepatitic reaction, and drugs such as chlorpromazine, erythromycins, amoxicillin-calvulanic acid, sulfonamides and sulindac trigger a cholestatic or mixed reaction. Unstable metabolites derived from the metabolism of the drug may bind to… CONTINUE READING
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