Immune-mediated brain atrophy. CD8+ T cells contribute to tissue destruction during borna disease.

@article{Bilzer1994ImmunemediatedBA,
  title={Immune-mediated brain atrophy. CD8+ T cells contribute to tissue destruction during borna disease.},
  author={Thomas Bilzer and Lothar Stitz},
  journal={Journal of immunology},
  year={1994},
  volume={153 2},
  pages={818-23}
}
Borna disease (BD) is a virus-induced immunopathologic disease of the central nervous system in a variety of species from birds to primates and probably in humans. Severe inflammatory reactions lead to tissue destruction and finally to cortical brain atrophy. After experimental infection of the rat, intraparenchymal CD8+ T cells, MHC class I Ags on Borna disease virus (BDV)-infected neurons, and numerous nerve cell lesions were present. Treatment of BDV-infected rats with the mAb OX-8 directed… CONTINUE READING

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