Immune mechanisms of allergen‐specific sublingual immunotherapy

@article{Moingeon2006ImmuneMO,
  title={Immune mechanisms of allergen‐specific sublingual immunotherapy},
  author={P. Moingeon and T. Batard and R. Fadel and F. Frati and J. Sieber and L. Overtvelt},
  journal={Allergy},
  year={2006},
  volume={61}
}
Sublingual immunotherapy has been shown in some clinical studies to modulate allergen‐specific antibody responses [with a decrease in the immunoglobulin E/immunoglobulin G4 (IgE/IgG4) ratio] and to reduce the recruitment and activation of proinflammatory cells in target mucosa. Whereas a central paradigm for successful immunotherapy has been to reorient the pattern of allergen‐specific T‐cell responses in atopic patients from a T helper (Th)2 to Th1 profile, there is currently a growing… Expand
Immunological mechanisms of sublingual immunotherapy
TLDR
Preliminary in vitro data suggest that SLIT may increase interleukin‐10, which has a clear role in suppressing the allergic immune response, and further studies are required to determine the involvement of regulatory T cells, the role of different dendritic cell subsets, mucosal B cells as well as the potential use of adjuvants during SLIT. Expand
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TLDR
Observations confirm the induction of strong allergen-specific suppressive/tolerogenic immune responses during SLIT and pave the ground for the identification of biomarkers of efficacy. Expand
Revue générale Mécanismes immunologiques de l'immunothérapie sublinguale spécifique des allergènes Immune mechanisms of allergen-specific sublingual immunotherapy
TLDR
A better understanding of immune mechanisms involved in sublingual immunotherapy will allow designing secondgeneration vaccines based on recombinant allergens presented in a native configuration to the immune system, in association with adjuvants and/or mucoadhesive formulations. Expand
An immunological overview of allergen specific immunotherapy — subcutaneous and sublingual routes
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TLDR
With an increase in understanding of the mechanism of regulatory pathways, promising progresses in the field of allergen-specific immunotherapy will ensue and may provide new options for the treatment of allergic disorders. Expand
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TLDR
The rapid induction scheme of sublingual immunotherapy induces an early immune suppression more effectively than the slower one, particularly when monomeric allergoids are utilized. Expand
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  • 2010
TLDR
An update on the immunological T cell responses induced by conventional subcutaneous and sublingual immunotherapy is provided, and a unifying view to reconciling the old dualism between immunoredirecting and immunoregulating mechanisms is given. Expand
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TLDR
First-generation sublingual vaccines are being developed, based upon recombinant allergens expressed in a native conformation, possibly formulated with Th1/T reg adjuvants and/or mucoadhesive particulate vector systems specifically designed to target oral dendritic cells. Expand
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TLDR
It is demonstrated that TAT‐fused rChe a 3 suppressed the allergic response through preferential enhancement of systemic regulatory T‐cell (Treg)‐mediated immunity responses, likely by facilitating allergen capture and presentation by sublingual Langerhans‐like dendritic cells. Expand
Tolerance induction after specific immunotherapy with pollen allergoids adjuvanted by monophosphoryl lipid A in children
TLDR
Short‐course immunotherapy with pollen allergoids formulated with the Th1‐inducing adjuvant MPL needs at least two courses to establish tolerance, and a significant antibody induction was seen only after the second course of SIT. Expand
Mechanisms of allergen-specific immunotherapy.
TLDR
The mechanisms of action of allergen-specific immunotherapy include the very early desensitization effects, modulation of T-and B-cell responses and related antibody isotypes, and migration of eosinophil, basophils, and mast cells to tissues, as well as release of their mediators. Expand
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