Immune mechanisms of allergen‐specific sublingual immunotherapy

@article{Moingeon2006ImmuneMO,
  title={Immune mechanisms of allergen‐specific sublingual immunotherapy},
  author={Philippe Moingeon and Thierry Batard and Riad Fadel and Franco Frati and Jochen Sieber and Laurence Van Overtvelt},
  journal={Allergy},
  year={2006},
  volume={61}
}
Sublingual immunotherapy has been shown in some clinical studies to modulate allergen‐specific antibody responses [with a decrease in the immunoglobulin E/immunoglobulin G4 (IgE/IgG4) ratio] and to reduce the recruitment and activation of proinflammatory cells in target mucosa. Whereas a central paradigm for successful immunotherapy has been to reorient the pattern of allergen‐specific T‐cell responses in atopic patients from a T helper (Th)2 to Th1 profile, there is currently a growing… 

Immunological mechanisms of sublingual immunotherapy

Preliminary in vitro data suggest that SLIT may increase interleukin‐10, which has a clear role in suppressing the allergic immune response, and further studies are required to determine the involvement of regulatory T cells, the role of different dendritic cell subsets, mucosal B cells as well as the potential use of adjuvants during SLIT.

Update on immune mechanisms associated with sublingual immunotherapy: practical implications for the clinician.

  • P. Moingeon
  • Biology, Medicine
    The journal of allergy and clinical immunology. In practice
  • 2013

Revue générale Mécanismes immunologiques de l'immunothérapie sublinguale spécifique des allergènes Immune mechanisms of allergen-specific sublingual immunotherapy

A better understanding of immune mechanisms involved in sublingual immunotherapy will allow designing secondgeneration vaccines based on recombinant allergens presented in a native configuration to the immune system, in association with adjuvants and/or mucoadhesive formulations.

An immunological overview of allergen specific immunotherapy — subcutaneous and sublingual routes

  • C. Ozdemir
  • Biology, Medicine
    Therapeutic advances in respiratory disease
  • 2009
With an increase in understanding of the mechanism of regulatory pathways, promising progresses in the field of allergen-specific immunotherapy will ensue and may provide new options for the treatment of allergic disorders.

T cell responses induced by allergen‐specific immunotherapy

  • E. Maggi
  • Medicine, Biology
    Clinical and experimental immunology
  • 2010
An update on the immunological T cell responses induced by conventional subcutaneous and sublingual immunotherapy is provided, and a unifying view to reconciling the old dualism between immunoredirecting and immunoregulating mechanisms is given.

Early Cytokine Modulation after the Rapid Induction Phase of Sublingual Immunotherapy with Mite Monomeric Allergoids

The rapid induction scheme of sublingual immunotherapy induces an early immune suppression more effectively than the slower one, particularly when monomeric allergoids are utilized.

Induction of Tolerance via the Sublingual Route: Mechanisms and Applications

First-generation sublingual vaccines are being developed, based upon recombinant allergens expressed in a native conformation, possibly formulated with Th1/T reg adjuvants and/or mucoadhesive particulate vector systems specifically designed to target oral dendritic cells.

Tolerance induction after specific immunotherapy with pollen allergoids adjuvanted by monophosphoryl lipid A in children

Short‐course immunotherapy with pollen allergoids formulated with the Th1‐inducing adjuvant MPL needs at least two courses to establish tolerance, and a significant antibody induction was seen only after the second course of SIT.

Mechanisms of allergen-specific immunotherapy.

  • C. AkdisM. Akdiş
  • Biology, Medicine
    The Journal of allergy and clinical immunology
  • 2011
...

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