Immune mechanisms of allergen‐specific sublingual immunotherapy

  title={Immune mechanisms of allergen‐specific sublingual immunotherapy},
  author={Philippe Moingeon and Thierry Batard and Riad Fadel and Franco Frati and Jochen Sieber and Laurence Van Overtvelt},
Sublingual immunotherapy has been shown in some clinical studies to modulate allergen‐specific antibody responses [with a decrease in the immunoglobulin E/immunoglobulin G4 (IgE/IgG4) ratio] and to reduce the recruitment and activation of proinflammatory cells in target mucosa. Whereas a central paradigm for successful immunotherapy has been to reorient the pattern of allergen‐specific T‐cell responses in atopic patients from a T helper (Th)2 to Th1 profile, there is currently a growing… 

Immunological mechanisms of sublingual immunotherapy

Preliminary in vitro data suggest that SLIT may increase interleukin‐10, which has a clear role in suppressing the allergic immune response, and further studies are required to determine the involvement of regulatory T cells, the role of different dendritic cell subsets, mucosal B cells as well as the potential use of adjuvants during SLIT.

Update on immune mechanisms associated with sublingual immunotherapy: practical implications for the clinician.

  • P. Moingeon
  • Biology, Medicine
    The journal of allergy and clinical immunology. In practice
  • 2013

Revue générale Mécanismes immunologiques de l'immunothérapie sublinguale spécifique des allergènes Immune mechanisms of allergen-specific sublingual immunotherapy

A better understanding of immune mechanisms involved in sublingual immunotherapy will allow designing secondgeneration vaccines based on recombinant allergens presented in a native configuration to the immune system, in association with adjuvants and/or mucoadhesive formulations.

An immunological overview of allergen specific immunotherapy — subcutaneous and sublingual routes

  • C. Ozdemir
  • Biology, Medicine
    Therapeutic advances in respiratory disease
  • 2009
With an increase in understanding of the mechanism of regulatory pathways, promising progresses in the field of allergen-specific immunotherapy will ensue and may provide new options for the treatment of allergic disorders.

T cell responses induced by allergen‐specific immunotherapy

  • E. Maggi
  • Medicine, Biology
    Clinical and experimental immunology
  • 2010
An update on the immunological T cell responses induced by conventional subcutaneous and sublingual immunotherapy is provided, and a unifying view to reconciling the old dualism between immunoredirecting and immunoregulating mechanisms is given.

Early Cytokine Modulation after the Rapid Induction Phase of Sublingual Immunotherapy with Mite Monomeric Allergoids

The rapid induction scheme of sublingual immunotherapy induces an early immune suppression more effectively than the slower one, particularly when monomeric allergoids are utilized.

Induction of Tolerance via the Sublingual Route: Mechanisms and Applications

First-generation sublingual vaccines are being developed, based upon recombinant allergens expressed in a native conformation, possibly formulated with Th1/T reg adjuvants and/or mucoadhesive particulate vector systems specifically designed to target oral dendritic cells.

Tolerance induction after specific immunotherapy with pollen allergoids adjuvanted by monophosphoryl lipid A in children

Short‐course immunotherapy with pollen allergoids formulated with the Th1‐inducing adjuvant MPL needs at least two courses to establish tolerance, and a significant antibody induction was seen only after the second course of SIT.

Mechanisms of allergen-specific immunotherapy.

  • C. AkdisM. Akdiş
  • Biology, Medicine
    The Journal of allergy and clinical immunology
  • 2011



Immunomodulation during sublingual therapy in allergic children

  • F. IppolitiW. De Santis T. Frediani
  • Medicine, Biology
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 2003
The results confirm the efficacy and safety of SLIT, and lead us to believe that it could modulate the synthesis of Th2 cytokines, as revealed from the decrease of IL‐13.

Interleukin‐10, T regulatory cells and specific allergy treatment

  • K. BlaserC. Akdis
  • Biology, Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2004
It was found that SIT generates regulatory T cells of the CD4 CD25 type, which secrete IL-10 and TGF-b and specifically suppress allergen-induced responses [16].

Lack of Detectable Alterations in Immune Responses during Sublingual Immunotherapy in Children with Seasonal Allergic Rhinoconjunctivitis to Grass Pollen

No significant effects on in vitro T-cell immune responses or immunoglobulins are observed during 2 years of SLIT in children with a positive effect on rescue medication use, probably due to limited effects ofSLIT on systemic immunologic reactions.

Mechanisms of immunotherapy.

IL‐10 and TGF‐β cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy

A deviation towards a regulatory/suppressor T cell response during SIT and in normal immunity as a key event for the healthy immune response to mucosal antigens is demonstrated.

Immunologic changes associated with allergen immunotherapy.

  • S. DurhamS. Till
  • Medicine, Biology
    The Journal of allergy and clinical immunology
  • 1998

T Regulatory Cells in Allergy and Health: A Question of Allergen Specificity and Balance

Induction of antigen-specific TReg cells may redirect an inappropriate immune response against allergen or autoantigens with the help of a broad range of suppressor mechanisms.

Induction of interleukin 10 by sublingual immunotherapy for house dust mites: a preliminary report.

  • G. CiprandiD. Fenoglio F. Puppo
  • Medicine, Biology
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 2005

Systemic Immunological Changes Induced by Administration of Grass Pollen Allergens via the Oral Mucosa during Sublingual Immunotherapy

Evidence is provided that sublingual treatment leads to systemic changes in immunoreactivity to the administered allergen, which is consistent with immune deviation in patients suffering from grass pollen allergy.

Renaissance of the Blocking Antibody Concept in Type I Allergy

Findings suggest that blocking antibodies have protective activity by inhibiting immediate as well as late inflammatory responses and long-term ameliorating activity on the allergic immune response by antagonizing the underlying IgE production.