Immune interactions in hepatic fibrosis.

  title={Immune interactions in hepatic fibrosis.},
  author={Andrew P. Holt and Mike Salmon and Christopher D Buckley and David H Adams},
  journal={Clinics in liver disease},
  volume={12 4},
  pages={861-82, x}
Liver cirrhosis is caused by iterative cycles of tissue injury, inflammation, and repair. Although most causes of acute hepatitis resolve without scarring, chronic hepatitis is associated with persistent inflammation and matrix remodeling, which leads to fibrosis and, eventually, cirrhosis. The mechanisms that govern wound healing involve interactions between the innate and adaptive immune systems and stromal cells within a microenvironment composed of cytokines, growth factors, and modified… CONTINUE READING


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