Immune function in sport and exercise.

@article{Gleeson2007ImmuneFI,
  title={Immune function in sport and exercise.},
  author={Michael Gleeson},
  journal={Journal of applied physiology},
  year={2007},
  volume={103 2},
  pages={
          693-9
        }
}
  • M. Gleeson
  • Published 1 August 2007
  • Medicine
  • Journal of applied physiology
Regular moderate exercise is associated with a reduced incidence of infection compared with a completely sedentary state. However, prolonged bouts of strenuous exercise cause a temporary depression of various aspects of immune function (e.g., neutrophil respiratory burst, lymphocyte proliferation, monocyte antigen presentation) that usually lasts approximately 3-24 h after exercise, depending on the intensity and duration of the exercise bout. Postexercise immune function dysfunction is most… 

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...

References

SHOWING 1-10 OF 58 REFERENCES

Exercise, nutrition and immune function.

To maintain immune function, athletes should eat a well-balanced diet sufficient to meet their energy requirements and consume 30-60 g carbohydrate x h(-1) during sustained intensive exercise, which appears to limit the degree of exercise-induced immune depression.

Effects of exercise intensity, duration and recovery on in vitro neutrophil function in male athletes.

It is concluded that when exercise is very prolonged, the diminution of innate immune function is greater, or at least as great as that observed after fatiguing exercise at higher work rates.

Leukocyte counts and lymphocyte responsiveness associated with repeated bouts of strenuous endurance exercise.

Differences in leukocyte counts and lymphocyte responsiveness during and after a second bout of high-intensity endurance exercise on the same day with the response to a similar but single bout of exercise suggest a "carry-over" effect in the immune system from a first to a second bouts of exercise onThe same day.

Mucosal immune responses and risk of respiratory illness in elite athletes.

This review focuses on studies of mucosal immunity in elite athletes and specifically addresses the role of mucosal immunity in respiratory illness and associations with the intensity, volume, and

Similarities and differences of the immune response to exercise and trauma: the IFN-γ concept

The hypothesis is presented that the rigorous regulatory blockade of one of the ways of IFN-γ induction may be critically involved in causing the transient immunosuppression following exhaustive exercise stress.

Effects of submaximal cycling and long-term endurance training on neutrophil phagocytic activity in middle aged men.

Although neutrophil phagocytic activity is only one variable that contributes to immunological status, prolonged periods of endurance training may lead to increased susceptibility to opportunistic infections by diminishing this activity at rest.

Exercise, infection, and immunity.

  • D. Nieman
  • Medicine
    International journal of sports medicine
  • 1994
Data at this time support a "J" curve relationship between risk of URTI and increasing exercise workloads, and changes in the immune system that might explain the altered risk of infection.

Immune responses and increased training of the elite athlete.

The immune system of endurance-trained athletes at rest seemed to tolerate the stress of heavy training, but superimposition of a bout of acute exercise on the chronic stress ofheavy training resulted in immunosuppression, which was transient and most likely not of clinical significance.

Acute infection: metabolic responses, effects on performance, interaction with exercise, and myocarditis.

Since myocarditis may or may not be associated with fever, malaise, or catarrhal symptoms, athletes should be taught the symptoms suggestive ofMyocarditis, and whenever myCarditis is suspected exercise should be avoided.

How Physical Exercise Influences the Establishment of Infections

During exercise, leucocytes are recruited to the blood, and if muscle damage occurs the cytokine level is enhanced, and in those performing regular moderate exercise the immune system will often be temporarily enhanced and this will protect these individuals from infections.
...