Immune function and leukocyte sequestration under the influence of parenteral lipid emulsions in healthy humans: a placebo-controlled crossover study.

@article{Versleijen2008ImmuneFA,
  title={Immune function and leukocyte sequestration under the influence of parenteral lipid emulsions in healthy humans: a placebo-controlled crossover study.},
  author={Michelle W J Versleijen and Wim J. G. Oyen and Hennie M. J. Roelofs and Sjenet E van Emst-de Vries and Peter H. G. M. Willems and Jan B. M. J. Jansen and Geert J. A. Wanten},
  journal={The American journal of clinical nutrition},
  year={2008},
  volume={87 3},
  pages={539-47}
}
BACKGROUND It remains unclear whether immune modulation by lipids contributes to the high risk of infectious complications that is associated with the use of parenteral nutrition. Although mixed long- and medium-chain triacylglycerol (LCT-MCT)-containing emulsions, but not pure LCT emulsions, activate neutrophils and impair crucial leukocyte functions in vitro, in vivo studies have failed to corroborate these findings. OBJECTIVES The present investigation was conducted to evaluate the effects… CONTINUE READING

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