Immune evasive mechanisms contributing to persistent Leishmania donovani infection

@article{Stger2010ImmuneEM,
  title={Immune evasive mechanisms contributing to persistent Leishmania donovani infection},
  author={Simona St{\"a}ger and Trupti Joshi and Rashmi Bankoti},
  journal={Immunologic Research},
  year={2010},
  volume={47},
  pages={14-24}
}
The protozoan parasite Leishmania donovani, a causative agent of visceral leishmaniasis, has evolved several strategies to interfere with the immune system and establish persistent infections that are potentially lethal. In this article, we discuss two mechanisms of immune evasion adopted by the parasite: the induction of immune suppressive IL-10 responses and the generation of poor and functionally impaired CD8+ T-cell responses. 

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    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2011
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The present work describes the need for this evaluation, and the techniques available for confirming whether these vaccines elicit a cell-mediated immune response, and a type of immune response.

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Exposure of human B cells to Leishmania infantum amastigotes triggers B cells with regulatory activities mediated in part by IL-10, which could favor parasite dissemination in the organism.

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Findings suggest that a new immunological scenario may occur when L. donovani and P. falciparum co-infect the same patient, with potential implications on the course and resolution of these diseases.

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It is noted that PKDL is a heterogeneous and dynamic condition and patients differ with regard to time of onset after visceral leishmaniasis (VL), chronicity, extent and appearance of the rash including related immune responses, all of which may vary over time.

T Cell-Derived IL-10 Determines Leishmaniasis Disease Outcome and Is Suppressed by a Dendritic Cell Based Vaccine

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IL-10 secretion by T cells has an influence on immune activation early after infection and is sufficient to render BALB/c mice susceptible to an uncontrolled Leishmania major infection.

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The significance of Leishmaniasis proteases in parasite lifecycle and their possible accountability as a new drug target is discussed with special emphasis on Leishmania serine proteases.

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