Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients.

@article{Crane2014ImmuneEM,
  title={Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients.},
  author={Courtney A. Crane and Kathryn Austgen and Kristen Haberthur and Carly Hofmann and Kara White Moyes and L. G. Avanesyan and Lawrence Fong and M J Campbell and Stewart L. Cooper and Scott A. Oakes and Andrew T. Parsa and Lewis L. Lanier},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 35},
  pages={12823-8}
}
Myeloid cells are key regulators of the tumor microenvironment, governing local immune responses. Here we report that tumor-infiltrating myeloid cells and circulating monocytes in patients with glioblastoma multiforme (GBM) express ligands for activating the Natural killer group 2, member D (NKG2D) receptor, which cause down-regulation of NKG2D on natural killer (NK) cells. Tumor-infiltrating NK cells isolated from GBM patients fail to lyse NKG2D ligand-expressing tumor cells. We demonstrate… CONTINUE READING

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  • 2010

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