Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF.

@article{Li2005ImmuneEB,
  title={Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF.},
  author={K. M. G. Li and Eileen M. Foy and Josephine C Ferreon and Mitsuyasu Nakamura and Allan Chris M Ferreon and Masanori Ikeda and Stuart C. Ray and Michael Gale and Stanley M Lemon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 8},
  pages={2992-7}
}
Toll-like receptors (TLRs) bind pathogen-specific ligands early in infection, initiating signaling pathways that lead to expression of multiple protective cellular genes. Many viruses have evolved strategies that block the effector mechanisms induced through these signaling pathways, but viral interference with critical proximal receptor interactions has not been described. We show here that the NS3/4A serine protease of hepatitis C virus (HCV), a virus notorious for its ability to establish… CONTINUE READING
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Hepatology 26, 21S–28S

  • L. B. Seeff
  • 1997

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