Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses.

@article{Kirchhoff2010ImmuneEA,
  title={Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses.},
  author={Frank Kirchhoff},
  journal={Cell host & microbe},
  year={2010},
  volume={8 1},
  pages={55-67}
}
Retroviruses have evolved effective strategies to evade the host immune response, such as high variability and latent infection. In addition, primate lentiviruses, such as HIV-1, have acquired several "accessory" genes that antagonize antiviral host restriction factors and facilitate viral immune evasion, thereby allowing continuous and efficient viral replication despite apparently strong innate and acquired immune responses. Here, I summarize some of our current knowledge on the acquisition… CONTINUE READING
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