Immune evasion: Mycobacteria hide from TLRs

  title={Immune evasion: Mycobacteria hide from TLRs},
  author={Elisabeth Kugelberg},
  journal={Nature Reviews Immunology},
Mycobacterium tuberculosis invades the host in small infectious droplets in the lower respiratory tract, rather than in the upper respiratory tract. Now, Ramakrishnan and colleagues suggest an explanation for these longstanding observations: pathogenic mycobacteria express membrane lipids that prevent the activation of microbicidal macrophages in the otherwise sterile lower respiratory tract. Microbial pathogen-associated molecular patterns (PAMPs) are recognized by Toll-like receptors (TLRs… CONTINUE READING
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