Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure).

@article{Kim2016ImmuneET,
  title={Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure).},
  author={J M Kim and D S Chen},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2016},
  volume={27 8},
  pages={1492-504}
}
The emergence of programmed death-ligand 1 (PD-L1)/programmed death-1 (PD-1)-targeted therapy has demonstrated the importance of the PD-L1 : PD-1 interaction in inhibiting anticancer T-cell immunity in multiple human cancers, generating durable responses and extended overall survival. However, not all patients treated with PD-L1/PD-1-targeted therapy experience tumor shrinkage, durable responses, or prolonged survival. To extend such benefits to more cancer patients, it is necessary to… CONTINUE READING
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