Immune escape mechanisms of childhood ALL and a potential countering role for DC-like leukemia cells.

Abstract

BACKGROUND Pre-B ALL cells generally elicit a weak immune host response, due to poor expression of co-stimulatory molecules and/or suppression of immune function. A possible way to enhance immunogenicity of pre-B ALL cells is to convert them to DC-like cells. METHODS To study the effect of ALL cells on T-cell function, ALL cells were incubated with T… (More)

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