Immune escape and survival mechanisms in circulating tumor cells of colorectal cancer.

  title={Immune escape and survival mechanisms in circulating tumor cells of colorectal cancer.},
  author={Gunnar Steinert and Sebastian Sch{\"o}lch and Thomas Niemietz and Naoki Iwata and Sebasti{\'a}n A. Garc{\'i}a and Bianca Behrens and Anita Yvonne Voigt and Matthias Kloor and Axel Benner and Ulrich Bork and Nuh N. Rahbari and Markus W. B{\"u}chler and Nikolas H Stoecklein and J{\"u}rgen Weitz and Moritz Koch},
  journal={Cancer research},
  volume={74 6},
The prognosis of colorectal cancer is closely linked to the occurrence of distant metastases. Systemic dissemination is most likely caused by circulating tumor cells (CTC). Despite the fundamental role of CTC within the metastatic cascade, technical obstacles have so far prevented detailed genomic and, in particular, phenotypic analyses of CTC, which may provide molecular targets to delay or prevent distant metastases. We show here a detailed genomic analysis of single colorectal cancer-derived… CONTINUE READING
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