Immune enhancing effect of a growth hormone secretagogue.

@article{Koo2001ImmuneEE,
  title={Immune enhancing effect of a growth hormone secretagogue.},
  author={Gloria C. Koo and Ching-Tai Huang and Ramon E. Camacho and Charlotte E. Trainor and Joseph T. Blake and Anna Sirotina-Meisher and Klaus Dieter Schleim and Tao-yiao John Wu and Kuo-Chen Cheng and Ravi P Nargund and Gaylord McKissick},
  journal={Journal of immunology},
  year={2001},
  volume={166 6},
  pages={4195-201}
}
Growth hormone (GH) has been known to enhance immune responses, whether directly or through the insulin like growth factor-1, induced by GH. Recently a nonpeptidyl small m.w. compound, a GH secretagogue (GHS), was found to induce the production of GH by the pituitary gland. In this study, we examined the effect of GHS in immunological functions of 5- to 6-wk-old and 16- to 24-month-old mice. In young mice, we observed a significant increase in PBLs, but T and B cell-proliferative responses were… CONTINUE READING
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