Immune enhancement and anti-tumour activity of IL-23

@article{Hao2006ImmuneEA,
  title={Immune enhancement and anti-tumour activity of IL-23},
  author={Jing-sheng Hao and Bao-en Shan},
  journal={Cancer Immunology, Immunotherapy},
  year={2006},
  volume={55},
  pages={1426-1431}
}
Immunotherapy, including the use of cytokines and/or modified tumour cells immune stimulatory cytokines, can enhance the host anti-tumour immune responses. Interleukin-23 (IL-23) is a relative novel cytokine, which consists of a heterodimer of the IL-12p40 subunit and a novel p19 subunit. IL-23 has biological activities similar to but distinct from IL-12. IL-23 can enhance the proliferation of memory T cells and the production of IFN-γ, IL-12 and TNF-α from activated T cells. IL-23 activates… CONTINUE READING

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