• Biology, Medicine
  • Published in Cancer research 1979

Immune elimination of host fibroblasts for the cultivation of human tumors transplanted into nude mice.

@article{Okabe1979ImmuneEO,
  title={Immune elimination of host fibroblasts for the cultivation of human tumors transplanted into nude mice.},
  author={Tetsuro Okabe and Akira Suzuki and Nakaaki Ohsawa and Kinori Kosaka and Toyozo Terasima},
  journal={Cancer research},
  year={1979},
  volume={39 10},
  pages={
          4189-94
        }
}
We report here a useful method for the isolation and cultivation of human tumor cells in vitro from human tumors grown in nude mice. A rabbit was immunized with spleen cells obtained from adult nude mice. The rabbit antiserum in the presence of complement effectively killed cultured cells derived from various mouse tissues, but it was not cytotoxic to cultured cells from human tissues including tumors. When mixed cultures consisting of human tumor cells and nude mouse fibroblasts were treated… CONTINUE READING

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