Immune effector mechanisms of the nitric oxide pathway in malaria: cytotoxicity versus cytoprotection.

  title={Immune effector mechanisms of the nitric oxide pathway in malaria: cytotoxicity versus cytoprotection.},
  author={Hossein Nahrevanian},
  journal={The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases},
  volume={10 4},
Nitric oxide (NO) is thought to be an important mediator and critical signaling molecule for malaria immunopathology; it is also a target for therapy and for vaccine. Inducible nitric oxide synthase (iNOS) is synthesized by a number of cell types under inflammatory conditions. The most relevant known triggers for its expression are endotoxins and cytokines. To date, there have been conflicting reports concerning the clinical significance of NO in malaria. Some researchers have proposed that NO… CONTINUE READING

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