Immune dysregulation in TGF-beta 1-deficient mice.

  title={Immune dysregulation in TGF-beta 1-deficient mice.},
  author={Matthias Hild Christ and Nancy L. McCartney-Francis and Ashok Kulkarni and Jerrold M Ward and Diane E. Mizel and Crystal L Mackall and Ronald E Gress and K L Hines and Huiyu Tian and Stefan Karlsson},
  journal={Journal of immunology},
  volume={153 5},
Approximately 2 wk after birth, mice having a TGF-beta 1 null mutation (TGF-beta 1(-/-)) exhibit a progressive wasting syndrome and death. Associated with this phenotype is a multifocal infiltration of lymphocytes and macrophages into target organs, especially the heart, lungs, and salivary glands. To explore the consequences of TGF-beta 1 deficiency on the immune system, lymphocyte phenotype and function were analyzed. Initially, lymphoid organ architecture seemed to be normal and, as symptoms… CONTINUE READING
Highly Cited
This paper has 83 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 82 citations

83 Citations

Citations per Year
Semantic Scholar estimates that this publication has 83 citations based on the available data.

See our FAQ for additional information.