Immune dysregulation in TGF-beta 1-deficient mice.

@article{Christ1994ImmuneDI,
  title={Immune dysregulation in TGF-beta 1-deficient mice.},
  author={Matthias Hild Christ and Nancy L. McCartney-Francis and Ashok Kulkarni and Jerrold M Ward and Diane E. Mizel and Crystal L Mackall and Ronald E Gress and K L Hines and Huiyu Tian and Stefan Karlsson},
  journal={Journal of immunology},
  year={1994},
  volume={153 5},
  pages={
          1936-46
        }
}
Approximately 2 wk after birth, mice having a TGF-beta 1 null mutation (TGF-beta 1(-/-)) exhibit a progressive wasting syndrome and death. Associated with this phenotype is a multifocal infiltration of lymphocytes and macrophages into target organs, especially the heart, lungs, and salivary glands. To explore the consequences of TGF-beta 1 deficiency on the immune system, lymphocyte phenotype and function were analyzed. Initially, lymphoid organ architecture seemed to be normal and, as symptoms… CONTINUE READING
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