A total of 193 patients with chronic alcoholism aged 30-65 years were examined. Optic nerve abnormalities were detected in 30 (15.5%) and degenerative condition of the retina in 42 (21.8%) patients. Ocular diseases were detected in 72 (37.3%) examined chronic alcoholics. Disorders of total and local immunity of the eye contribute to the development of the above diseases. These changes were more pronounced in chronic alcoholics with visual analyzer abnormalities. These data can be useful in development of pathogenetic therapy of ocular diseases.