Immune derived opioidergic inhibition of viscerosensory afferents is decreased in Irritable Bowel Syndrome patients.

@article{Hughes2014ImmuneDO,
  title={Immune derived opioidergic inhibition of viscerosensory afferents is decreased in Irritable Bowel Syndrome patients.},
  author={Patrick A Hughes and Melissa Moretta and Amanda H Lim and Dallas J Grasby and Daniel R G Bird and Stuart M Brierley and Tobias Liebregts and Birgit Adam and L Ashley Blackshaw and Gerald Holtmann and Peter A. Bampton and Peter Hoffmann and J M Andrews and Heddy Zola and Doreen Krumbiegel},
  journal={Brain, behavior, and immunity},
  year={2014},
  volume={42},
  pages={191-203}
}
Alterations in the neuro-immune axis contribute toward viscerosensory nerve sensitivity and symptoms in Irritable Bowel Syndrome (IBS). Inhibitory factors secreted from immune cells inhibit colo-rectal afferents in health, and loss of this inhibition may lead to hypersensitivity and symptoms. We aimed to determine the immune cell type(s) responsible for opioid secretion in humans and whether this is altered in patients with IBS. The β-endorphin content of specific immune cell lineages in… CONTINUE READING