Immune-dependent and independent antitumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors.

@article{Urdinguio2013ImmunedependentAI,
  title={Immune-dependent and independent antitumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors.},
  author={Roc{\'i}o Gonz{\'a}lez Urdinguio and Agust{\'i}n F. Fern{\'a}ndez and Angela Moncada-Pazos and Covadonga Huidobro and Ram{\'o}n Mar{\'i}a Alvargonz{\'a}lez Rodr{\'i}guez and Cecilia Ferrero and Pablo Mart{\'i}nez-Camblor and Alvaro J Obaya and Teresa Bernal and Adolfo Parra-Blanco and Luis Rodrigo and Maria Santacana and Xavier Mat{\'i}as-Guiu and Beatriz Soldevilla and Gemma Dom{\'i}nguez and F{\'e}lix Bonilla and Santiago Cal and Carlos L{\'o}pez-Ot{\'i}n and Mario F Fraga},
  journal={Cancer research},
  year={2013},
  volume={73 1},
  pages={
          395-405
        }
}
Granulocyte-macrophage colony-stimulating factor (GM-CSF/CSF2) is a cytokine produced in the hematologic compartment that may enhance antitumor immune responses, mainly by activation of dendritic cells. Here, we show that more than one-third of human colorectal tumors exhibit aberrant DNA demethylation of the GM-CSF promoter and overexpress the cytokine. Mouse engraftment experiments with autologous and homologous colon tumors engineered to repress the ectopic secretion of GM-CSF revealed the… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 53 REFERENCES

Natural innate and adaptive immunity to cancer.

VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Cellular vaccine approaches.

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Epigenetic regulation in cancer development.

VIEW 1 EXCERPT