Immune-deficient mouse models for analysis of human stem cells.

  title={Immune-deficient mouse models for analysis of human stem cells.},
  author={Todd E. Meyerrose and Phillip E. Herrbrich and David A Hess and Jan A Nolta},
  volume={35 6},
The field of murine models of xenotransplantation has grown immensely over the past two decades. The explosive growth in this field is in part due to the fact that good in vitro methods do not exist yet to allow examination of human stem cell homing into the bone marrow compartment versus other tissues, long-term survival of human stem cells, or differentiation into tissues outside of the hematopoietic system. Since these important aspects of human stem cell biology can be examined in vivo… CONTINUE READING

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