Immune complexes and IFN-gamma decrease cholesterol 27-hydroxylase in human arterial endothelium and macrophages.

@article{Reiss2001ImmuneCA,
  title={Immune complexes and IFN-gamma decrease cholesterol 27-hydroxylase in human arterial endothelium and macrophages.},
  author={Allison B. Reiss and Nahel W. Awadallah and Shikha Malhotra and Mar{\'i}a Carmen Montesinos and Edwin S. L. Chan and Normal B Javitt and Bruce Cronstein},
  journal={Journal of lipid research},
  year={2001},
  volume={42 11},
  pages={1913-22}
}
The enzyme cholesterol 27-hydroxylase, expressed by arterial endothelium and monocytes/macrophages, is one of the first lines of defense against the development of atherosclerosis. By catalyzing the hydroxylation of cholesterol to 27-hydroxycholesterol, which is more soluble in aqueous medium, the enzyme promotes the removal of cholesterol from the arterial wall. Prior studies have suggested that immune reactants play a role in the pathogenesis of atherosclerosis; we report here that immune… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Similar Papers

Loading similar papers…