Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood

  title={Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood},
  author={Yaniv Ziv and Noga Ron and Oleg Butovsky and Gennady Landa and Einav Sudai and Nadav Greenberg and Hagit Cohen and Jonathan Kipnis and Michal Schwartz},
  journal={Nature Neuroscience},
Neurogenesis is known to take place in the adult brain. This work identifies T lymphocytes and microglia as being important to the maintenance of hippocampal neurogenesis and spatial learning abilities in adulthood. Hippocampal neurogenesis induced by an enriched environment was associated with the recruitment of T cells and the activation of microglia. In immune-deficient mice, hippocampal neurogenesis was markedly impaired and could not be enhanced by environmental enrichment, but was… 

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