Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood

@article{Ziv2006ImmuneCC,
  title={Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood},
  author={Yaniv Ziv and Noga Ron and Oleg Butovsky and Gennady Landa and Einav Sudai and Nadav Greenberg and Hagit Cohen and Jonathan Kipnis and Michal Schwartz},
  journal={Nature Neuroscience},
  year={2006},
  volume={9},
  pages={268-275}
}
Neurogenesis is known to take place in the adult brain. This work identifies T lymphocytes and microglia as being important to the maintenance of hippocampal neurogenesis and spatial learning abilities in adulthood. Hippocampal neurogenesis induced by an enriched environment was associated with the recruitment of T cells and the activation of microglia. In immune-deficient mice, hippocampal neurogenesis was markedly impaired and could not be enhanced by environmental enrichment, but was… Expand

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References

SHOWING 1-10 OF 61 REFERENCES
Inflammation is detrimental for neurogenesis in adult brain
TLDR
It is demonstrated that lipopolysaccharide-induced inflammation, which gives rise to microglia activation in the area where the new neurons are born, strongly impairs basal hippocampal neurogenesis in rats, raising the possibility that suppression of hippocampal Neurogenesis by activatedmicroglia contributes to cognitive dysfunction in aging, dementia, epilepsy, and other conditions leading to brain inflammation. Expand
Learning enhances adult neurogenesis in the hippocampal formation
TLDR
It is reported that the number of adult-generated neurons doubles in the rat dentate gyrus in response to training on associative learning tasks that require the hippocampus, which indicates that adult- generated hippocampal neurons are specifically affected by, and potentially involved in, associative memory formation. Expand
A role for adult neurogenesis in spatial long-term memory
TLDR
It is shown that new neurons aged 4-28 days old at the time of training are required for long-term memory in a spatial version of the water maze, suggesting a new role for adult neurogenesis in the formation and/or consolidation of long- term, hippocampus-dependent, spatial memories. Expand
Neurogenesis may relate to some but not all types of hippocampal‐dependent learning
TLDR
The results combined with previous ones suggest that neurogenesis may be associated with the formation of some but not all types of hippocampal‐dependent memories. Expand
Migration and differentiation of neural precursor cells can be directed by microglia
TLDR
It is shown, in two different assays, that soluble factors released from mouse microglial cells direct the migration of neural CNS precursor cells and evidence is provided that microglia have the capacity to influence the differentiation of both adult and embryonic neural precursor cells toward a neuronal phenotype. Expand
Neurogenesis in the adult is involved in the formation of trace memories
TLDR
It is shown that a substantial reduction in the number of newly generated neurons in the adult rat impairs hippocampal-dependent trace conditioning, a task in which an animal must associate stimuli that are separated in time. Expand
Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells
TLDR
A discussion of what the function might be of newly generated neurons in the adult brain and a summary of current thinking about the consequences of disturbed adult neurogenesis and the reaction of neurogenic regions to disease are provided. Expand
Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis
TLDR
The discrepancy between the olfactory bulb and the dentate gyrus suggests that these living conditions trigger locally through an as yet unidentified mechanism specific to neurogenic signals in the dentates gyrus. Expand
Early life experience alters response of adult neurogenesis to stress
TLDR
The results suggest that early adverse experience inhibits structural plasticity via hypersensitivity to glucocorticoids and diminishes the ability of the hippocampus to respond to stress in adulthood. Expand
Microglia activated by IL-4 or IFN-γ differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells
TLDR
It appears that microglial phenotype critically affects their ability to support or impair cell renewal from adult stem cell, and this effect is mediated by insulin-like growth factor-I. Expand
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5
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