Immune cell infiltration in corneas of mice with recurrent herpes simplex virus disease.

@article{Shimeld1996ImmuneCI,
  title={Immune cell infiltration in corneas of mice with recurrent herpes simplex virus disease.},
  author={Carolyn Shimeld and J L Whiteland and Susan M Nicholls and David L. Easty and Terry J. Hill},
  journal={The Journal of general virology},
  year={1996},
  volume={77 ( Pt 5)},
  pages={977-85}
}
Reactivation of latent herpes simplex virus type 1 (HSV-1) infection was induced by UV irradiation of the corneas of latently infected mice. On days 1-4 after stimulation, infectious virus was sought in nervous and ocular tissue. On days 4, 7 and 10, eyes with either recurrent epithelial or stromal disease and appropriate controls were stained to identify immune cells and HSV-1 antigens. The maximum incidence of infectious virus was on day 2 when 5/10 ophthalmic parts of the trigeminal ganglion… CONTINUE READING