Immune cell dysfunction and inflammation in end-stage renal disease

  title={Immune cell dysfunction and inflammation in end-stage renal disease},
  author={M. G. Betjes},
  journal={Nature Reviews Nephrology},
  • M. G. Betjes
  • Published 2013
  • Medicine
  • Nature Reviews Nephrology
  • Uraemia causes inflammation and reduces immune system function as evidenced by an increased risk of viral-associated cancers, increased susceptibility to infections and decreased vaccination responses in patients with end-stage renal disease (ESRD). The substantially increased risk of atherosclerosis in these patients is also probably related to uraemia-associated inflammation. Uraemia is associated with a reduction in the number and function of lymphoid cells, whereas numbers of myeloid cells… CONTINUE READING
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    Paper Mentions

    The current incidence of chronic kidney disease (CKD) in China is approximately 10.8%, with approximately 119 million patients. Among them, patients with end-stage renal disease (ESRD… Expand
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