Immune cell crosstalk in obesity: a key role for costimulation?

  title={Immune cell crosstalk in obesity: a key role for costimulation?},
  author={Tom Seijkens and Pascal J. H. Kusters and Antonios Chatzigeorgiou and Triantafyllos Chavakis and Esther Lutgens},
  volume={63 12},
In the past two decades, numerous experimental and clinical studies have established the importance of inflammation and immunity in the development of obesity and its metabolic complications, including insulin resistance and type 2 diabetes mellitus. In this context, T cells orchestrate inflammatory processes in metabolic organs, such as the adipose tissue (AT) and liver, thereby mediating obesity-related metabolic deterioration. Costimulatory molecules, which are present on antigen-presenting… CONTINUE READING
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