Immune cell Toll-like receptor 4 mediates the development of obesity- and endotoxemia-associated adipose tissue fibrosis.

@article{Vila2014ImmuneCT,
  title={Immune cell Toll-like receptor 4 mediates the development of obesity- and endotoxemia-associated adipose tissue fibrosis.},
  author={Isabelle K Vila and Pierre-Marie Badin and Marie-Adeline Marqu{\'e}s and Laurent Monbrun and Corinne Lefort and Lucile Mir and Katie Louche and Virginie Bourlier and Balbine Roussel and Philippe Gui and Jacques Grober and Vladim{\'i}r {\vS}tich and Lenka Rossmeislov{\'a} and Alexia Zakaroff-Girard and Anne Bouloumi{\'e} and Nathalie Viguerie and C{\'e}dric Moro and Genevi{\`e}ve Tavernier and Dominique Langin},
  journal={Cell reports},
  year={2014},
  volume={7 4},
  pages={
          1116-29
        }
}
  • Isabelle K Vila, Pierre-Marie Badin, +16 authors Dominique Langin
  • Published in Cell reports 2014
  • Medicine, Biology
  • Adipose tissue fibrosis development blocks adipocyte hypertrophy and favors ectopic lipid accumulation. Here, we show that adipose tissue fibrosis is associated with obesity and insulin resistance in humans and mice. Kinetic studies in C3H mice fed a high-fat diet show activation of macrophages and progression of fibrosis along with adipocyte metabolic dysfunction and death. Adipose tissue fibrosis is attenuated by macrophage depletion. Impairment of Toll-like receptor 4 signaling protects mice… CONTINUE READING

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