Immune and inflammatory responses to Leishmania amazonensis isolated from different clinical forms of human leishmaniasis in CBA mice.

@article{Souza2011ImmuneAI,
  title={Immune and inflammatory responses to Leishmania amazonensis isolated from different clinical forms of human leishmaniasis in CBA mice.},
  author={Valderes Lemos de Souza and Patr{\'i}cia Sampaio Tavares Veras and Marcus Welby-Borges and T{\^a}nia Maria Correia Silva and B. R. B. Leite and Rodrigo Barbosa Ferraro and Jos{\'e} Roberto Meyer-Fernandes and Aldina Barral and Jackson Maur{\'i}cio Lopes Costa and Luiz Ant{\^o}nio Rodrigues de Freitas},
  journal={Memorias do Instituto Oswaldo Cruz},
  year={2011},
  volume={106 1},
  pages={23-31}
}
Leishmania amazonensis causes different diseases depending on the host and parasitic virulence factors. In this study, CBA mice were infected with L. amazonensis isolates from patients with localized (Ba125), diffuse cutaneous (Ba276) or visceral leishmaniasis (Ba109). Mice infected with Ba125 and Ba276 progressed rapidly and lesions displayed an infiltrate rich in parasitized macrophages and were necrotic and ulcerated. Ba109 induced smaller lesions and a mixed inflammatory infiltrate without… CONTINUE READING