Immune and clinical parameters associated with Leishmania infantum infection in the golden hamster model.

@article{Requena2000ImmuneAC,
  title={Immune and clinical parameters associated with Leishmania infantum infection in the golden hamster model.},
  author={Jose M Requena and Manuel Soto and Maria do C{\'e}u D{\'o}ria and Carlos Alonso},
  journal={Veterinary immunology and immunopathology},
  year={2000},
  volume={76 3-4},
  pages={269-81}
}
For experimental infections with viscerotropic strains of Leishmania, a suitable animal model is not yet defined. In the present work, we have reappraised the use of golden hamster (Mesocricetus auratus) as an experimental model for infection with Leishmania infantum. Groups of hamsters were challenged by the intracardial route with doses ranging from 10(3) to 10(5) infectious promastigotes and the animals were monitored for 1-year follow-up period. The outcome of the infection was assessed by… CONTINUE READING