Immune aging and autoimmunity

@article{Goronzy2012ImmuneAA,
  title={Immune aging and autoimmunity},
  author={J{\"o}rg J Goronzy and Cornelia M Weyand},
  journal={Cellular and Molecular Life Sciences},
  year={2012},
  volume={69},
  pages={1615-1623}
}
Age is an important risk for autoimmunity, and many autoimmune diseases preferentially occur in the second half of adulthood when immune competence has declined and thymic T cell generation has ceased. Many tolerance checkpoints have to fail for an autoimmune disease to develop, and several of those are susceptible to the immune aging process. Homeostatic T cell proliferation which is mainly responsible for T cell replenishment during adulthood can lead to the selection of T cells with… CONTINUE READING

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