Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells.

@article{Swaims2010ImmuneAI,
  title={Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells.},
  author={Alison Y Swaims and Francesca Khani and Yingyu Zhang and Arthur I. Roberts and Satish Devadas and Yufang Shi and Arnold B. Rabson},
  journal={Blood},
  year={2010},
  volume={116 16},
  pages={2994-3003}
}
Infection with the human T-cell leukemia virus-1 (HTLV-1) results in a variety of diseases including adult T-cell leukemia/lymphoma (ATL). Although the pathogenesis of these disorders is poorly understood, it involves complex interactions with the host immune system. Activation of infected T cells may play an important role in disease pathogenesis through induction of the oncogenic HTLV-1 Tax transactivator protein. To test this hypothesis, we employed transgenic mice in which Tax is regulated… CONTINUE READING

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