Immune activation and inflammation in HIV‐1 infection: causes and consequences

@article{Appay2008ImmuneAA,
  title={Immune activation and inflammation in HIV‐1 infection: causes and consequences},
  author={V. Appay and D. Sauce},
  journal={The Journal of Pathology},
  year={2008},
  volume={214}
}
Thorough research on HIV is progressively enabling us to understand the intricate mechanisms that link HIV‐1 infection to the onset of immunodeficiency. The infection and depletion of CD4+ T cells represent the most fundamental events in HIV‐1 infection. However, in recent years, the role played by chronic immune activation and inflammation in HIV pathogenesis has become increasingly apparent: quite paradoxically, immune activation levels are directly associated with HIV‐1 disease progression… Expand
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References

SHOWING 1-10 OF 163 REFERENCES
HIV and inflammation.
Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection
Premature ageing of the immune system: the cause of AIDS?
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Proinflammatory cytokines in HIV disease-a review and rationale for new therapeutic approaches.
Persistent immune activation in HIV-1 infection is associated with progression to AIDS
Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasis.
CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract
Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection.
Latency and viral persistence in HIV-1 infection.
...
1
2
3
4
5
...