Immune activation and inflammation in HIV‐1 infection: causes and consequences

  title={Immune activation and inflammation in HIV‐1 infection: causes and consequences},
  author={Victor Appay and Delphine Sauce},
  journal={The Journal of Pathology},
Thorough research on HIV is progressively enabling us to understand the intricate mechanisms that link HIV‐1 infection to the onset of immunodeficiency. The infection and depletion of CD4+ T cells represent the most fundamental events in HIV‐1 infection. However, in recent years, the role played by chronic immune activation and inflammation in HIV pathogenesis has become increasingly apparent: quite paradoxically, immune activation levels are directly associated with HIV‐1 disease progression… 
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The comparison between HIV-1 infected patients and uninfected elderly individuals goes beyond the sole onset of immunosenescence and extends to the deterioration of several physiological functions related to inflammation and systemic aging.
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The long-term management of the disease will incorporate both the identification and the amelioration of the potentially harmful effects of ongoing immune activation and inflammation, which are broad concepts involving the interaction of various key players in the immune system.
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  • H. Ipp, A. Zemlin
  • Biology, Medicine
    Clinica chimica acta; international journal of clinical chemistry
  • 2013
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Increased T cell activation has predictive value for HIV-1 disease progression even before seroconversion, and the hypothesis that persistent hyperactivation of the immune system may lead to erosion of the naive T cell pool and CD4 T cell depletion is supported.
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