Immune activation and inflammation in HIV‐1 infection: causes and consequences
@article{Appay2008ImmuneAA, title={Immune activation and inflammation in HIV‐1 infection: causes and consequences}, author={Victor Appay and Delphine Sauce}, journal={The Journal of Pathology}, year={2008}, volume={214} }
Thorough research on HIV is progressively enabling us to understand the intricate mechanisms that link HIV‐1 infection to the onset of immunodeficiency. The infection and depletion of CD4+ T cells represent the most fundamental events in HIV‐1 infection. However, in recent years, the role played by chronic immune activation and inflammation in HIV pathogenesis has become increasingly apparent: quite paradoxically, immune activation levels are directly associated with HIV‐1 disease progression…
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