Immune activation and inflammation in HIV‐1 infection: causes and consequences

@article{Appay2008ImmuneAA,
  title={Immune activation and inflammation in HIV‐1 infection: causes and consequences},
  author={Victor Appay and Delphine Sauce},
  journal={The Journal of Pathology},
  year={2008},
  volume={214}
}
Thorough research on HIV is progressively enabling us to understand the intricate mechanisms that link HIV‐1 infection to the onset of immunodeficiency. The infection and depletion of CD4+ T cells represent the most fundamental events in HIV‐1 infection. However, in recent years, the role played by chronic immune activation and inflammation in HIV pathogenesis has become increasingly apparent: quite paradoxically, immune activation levels are directly associated with HIV‐1 disease progression… 
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